Complete genome sequence and bioinformatics analysis of nine Egyptian females with clinical information from different geographic regions in Egypt

Egyptians are at a crossroad between Africa and Eurasia, providing useful genomic resources for analyzing both genetic environmental factors future personalized medicine. Two personal Egyptian whole genomes have been published previously by us here nine female genome sequences with clinical information added to expand the resource of genomes. Here we report analysis females from different regions using Illumina short-read sequencers. At 30x sequencing coverage, identified 12 SNPs that were shared in most subjects associated obesity which concordant their diagnosis. Also, found mtDNA mutation A4282G is common all samples this chronic progressive external ophthalmoplegia (CPEO). Haplogroup Admixture analyses revealed close other north Mediterranean, Middle Eastern, European, respectively, possibly reflecting into-Africa influx human migration. In conclusion, present whole-genome cover diverse Egypt. Although limited sample size, data provides possible geno-phenotype candidate markers relevant region’s diseases.